Endothelial progenitor cells as putative targets for angiostatin.

Looking for immortality: Review of phytotherapy for stem cell senescence

Objective(s): In this paper, we discussed natural agents with protective effects against stem cell senescence. Different complications have been observed due to stem cell senescence and the most important of them is “Aging”. Senescent cells have not normal function and their secretary inflammatory factors induce chronic inflammation in body which causes different patho...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

Effect of two different intensity of physical activity on circulating endothelial progenitor cells (EPC) in healthy young women

The purpose of this study was to determine the effect of two different intensities of physical activity on circulating endothelial progenitor cells (EPC) in healthy young women. For this purpose, 15 female students from volunteers were randomly selected via questionnaire (group 1: mean age 22 ±1/8 years, BMI 20/81±1/91 kg/m2, n = 8. group 2: mean age 21 ±1/5 years, BMI 20/38 ± 1/66 kg/m2, ...

Specification of Hemato-Endothelial-Like Structures and Generation of Hematopoietic Progenitor Cells from Human Pluripotent Stem Cells

 Background and purpose: Human pluripotent stem cells (hPSCs) with the ability to differentiate into adult cells have provided a new perspective for treatment of some diseases. But, the efficiency of differentiation methods to generate hematopoietic progenitor cells (HPCs) is faced with multiple challenges. In the present study, we investigated the formation of hemato-endothelial-like structure...

Angiomotin: An Angiostatin Binding Protein That Regulates Endothelial Cell Migration and Tube Formation

Angiostatin, a circulating inhibitor of angiogenesis, was identified by its ability to maintain dormancy of established metastases in vivo. In vitro, angiostatin inhibits endothelial cell migration, proliferation, and tube formation, and induces apoptosis in a cell type–specific manner. We have used a construct encoding the kringle domains 1–4 of angiostatin to screen a placenta yeast two-hybri...